Week 26 Posted on July 10, 2023 by Riya Ghandi Please answer the following questions: Step 1 of 2 50% Please read the following scenario and choose the most appropriate answer.(Required) Refer the request to a microbiologist, hospital pharmacist or infectious diseases physician. Release only the ceftazidime MIC. Report the standard (ie. ceftazidime) as susceptible. Report all the third generation cephalosporins as resistant. Report only the ceftriaxone result. A patient with meningitis from which a Klebsiella species was isolated from the CSF (patient was a cancer patient with a line in place for intrathecal administration of methotrexate). The Klebsiella species was resistant only to ampicillin and SXT. Third generation cephalosporins (ceftazidime, and ceftriaxone) on the labs test panel were all susceptible. The hospital formu-lary had ceftazidime, which is a standard third generation cephalosporin, so the physician asked that it be reported. How would you proceed? Please select the correct statement(s)(Required) Largely because of their low lipophilicity, cephalosporins poorly penetrate through the blood-brain barrier, achieving relatively low cerebrospinal fluid (CSF) concentrations. Because extended spectrum cephalosporins poorly penetrate though the blood-brain barrier, CSF drug concentrations may not achieve the minimum bactericidal concentrations for common meningeal pathogens. In the setting presented in VC212: an acute complex illness with a high risk of fatal outcome, the most appropriate and useful action would be to refer the request of a microbiologist, hospital pharmacist, or infectious diseases physician.
